5 Key Takeaways

• 1

  New topical prescription therapies for presbyopia and dry eye disease include pilocarpine, aceclidine, and acoltremon.

• 2

  Pilocarpine 0.4% shows significant improvement in near visual acuity, with 52.9% of patients achieving 20/40 DCNVA or better by day 15.

• 3

  Aceclidine 1.44% has a dosing regimen of 2 drops once daily and demonstrates a rapid onset of effect, with 71% of participants improving within 0.5 hours.

• 4

  Acoltremon 0.003% stimulates tear production and met primary endpoints in phase 3 trials, showing significant improvements in dry eye symptoms.

• 5

  Topical miotics are approved for all adults with presbyopia, including post-LASIK patients, while acoltremon is suitable for various dry eye subtypes.