Managing Glaucoma With Selective Laser Trabeculoplasty (SLT) and DSLT
Overview
Selective laser trabeculoplasty (SLT) remains a valuable treatment for open-angle and secondary glaucomas, effectively lowering intraocular pressure (IOP) while preserving visual function and quality of life. Emerging direct SLT (DSLT) offers a rapid, noncontact alternative with comparable efficacy and increased efficiency, expanding treatment options in glaucoma care.
Background
Glaucoma management centers on lowering IOP to preserve visual acuity, visual fields, and patient quality of life. SLT is established as a first-line or adjunctive therapy for open-angle glaucoma and secondary glaucomas such as pseudoexfoliation and pigmentary dispersion glaucoma. Recent trials, including LiGHT and COAST, support SLT's efficacy and safety. DSLT, a newer noncontact laser modality, delivers automated shots quickly and may be performed by optometrists in some regions, potentially increasing access to laser treatment.
Data Highlights
| Study | Finding |
|---|---|
| Los Angeles Latino Eye Study | Vision-related quality of life worsens with monocular and binocular visual field loss; severe VF loss linked to mental health concerns |
| LiGHT Trial | SLT effective as first-line treatment for ocular hypertension and glaucoma |
| GLAUrious Trial | Minimal difference in mean IOP reduction between SLT and DSLT |
| Glaucoma Treatment Preferences Study | 55% patients prefer drops; 6.3% prefer intraocular surgery over medications |
| Market Scope Q4 2024 | Increasing optometric confidence in SLT utilization |
Key Findings
- SLT effectively lowers IOP and can be used as first-line treatment in phakic and pseudophakic patients without cataract or corneal edema.
- Postoperative management has evolved to omit routine use of postlaser brimonidine, steroids, or NSAIDs, with IOP checks recommended at 8-12 weeks and new visual field/OCT baselines at 3-6 months.
- DSLT is a noncontact, rapid procedure delivering 120 automated shots in under 3.5 seconds per eye, with efficacy comparable to conventional SLT but slightly less potent.
- DSLT can be performed undilated and by optometrists in several states, potentially improving patient access and clinic efficiency.
- Patient preferences show a majority favoring drops over drug delivery systems, but a minority prefer surgical options; optometric confidence in SLT is rising.
- SLT may reduce the need for topical glaucoma medications postoperatively, lowering treatment burden.
Clinical Implications
Clinicians should consider SLT as an effective and patient-friendly first-line or adjunctive therapy for open-angle and secondary glaucomas, especially in patients without contraindications such as cataract or corneal edema. DSLT offers a promising, efficient alternative that may expand access to laser treatment, particularly in optometric settings. Postoperative protocols can be simplified, focusing on scheduled IOP monitoring and imaging to optimize outcomes while minimizing medication burden.
Conclusion
SLT remains a cornerstone in glaucoma management, balancing efficacy with quality of life benefits. The advent of DSLT enhances treatment efficiency and accessibility, supporting a more interventional approach that may reduce reliance on medications and improve patient care.
References
- Varma R et al. 2004 -- The Los Angeles Latino Eye Study
- Gazzard G et al. 2019 -- LiGHT Trial: SLT vs Eye Drops
- Melamed S et al. 2003 -- SLT as Primary Treatment for Open-Angle Glaucoma
- Belkin Vision 2023 -- GLAUrious Trial Long-Term Follow-Up
- SooHoo JR et al. 2026 -- Glaucoma Patient Treatment Preferences
- Market Scope 2024 -- Ophthalmic Market Trends: US Glaucoma Edition Q4 2024
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.


